ArticleCells2026
Differential Regulation of Protective and Harmful Renin Transcripts by the cAMP/PKA/Ca
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Two different renin isoforms are expressed in extrarenal tissues. The classical renin-a has been associated with detrimental effects, whereas renin-b exerts protective effects during glucose starvation. Glucose starvation selectively increased renin-b mRNA levels. 8Br-cAMP increased renin-a mRNA levels independently of glucose as well as of renin-b in glucose-starved cells. Adenylyl cyclase (AC) stimulation by forskolin increased expression of both renin transcripts, while AC inhibition by SQ22536 produced the opposite effect. PKA inhibition by KT5720 reduced the mRNA levels of both renin transcripts glucose-independently. Forskolin reversed the effect of KT5720 on renin mRNA levels. A23187-mediated increase in [Ca
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