Evidence map›Paper›PMID 42505388›Full record

ArticleCells2026

Optimized Isolation and Cryopreservation of Functional Mitochondria for Transplantation and Therapeutic Applications.

Vikky Awasthi, Aasthika Das, Meriem Bkhache, Abeer Alshambky, Glenn S Gerhard, Karim Bahmed, Timothy Cashman, Rihab Bouchareb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vikky AwasthiCenter for Metabolic Disease Research (CMDR), Department of Cardiovascular Sciences, Lewis Katz School of Medicine (LKSM), Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
Aasthika DasCenter for Metabolic Disease Research (CMDR), Department of Cardiovascular Sciences, Lewis Katz School of Medicine (LKSM), Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
Meriem BkhacheCenter for Metabolic Disease Research (CMDR), Department of Cardiovascular Sciences, Lewis Katz School of Medicine (LKSM), Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
Abeer AlshambkyCenter for Metabolic Disease Research (CMDR), Department of Cardiovascular Sciences, Lewis Katz School of Medicine (LKSM), Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
Glenn S GerhardDepartment of Medical Genetics and Molecular Biochemistry, Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
Karim BahmedCenter for Inflammation and Lung Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Timothy CashmanTemple Heart & Vascular Institute, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0001-6238-129X
Rihab BoucharebCenter for Metabolic Disease Research (CMDR), Department of Cardiovascular Sciences, Lewis Katz School of Medicine (LKSM), Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.ORCID 0000-0002-6468-1269

Funding

Coordinating Unit for the Innovative Science Accelerator ProgramU24DK128851 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2021 to 2025
$6.7M
Platelet-mitochondria transplantation to treat mitochondrial dysfunction in acute kidney injuryR01DK135470 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI Rihab Bouchareb · 2023 to 2026
$1.3M
NIDDK NIH HHS R01 DK135470NIDDK NIH HHS U24 DK128851
6 · The paper itself

Abstract

Mitochondria play a central role in numerous physiological and pathological processes, and mitochondrial transplantation is emerging as a promising strategy to restore cellular function and mitigate disease. The success of this approach depends critically on the methods used to isolate, preserve, and retrieve intact, functional mitochondria.

Indexed as

Cytological TechniquesMitochondriaAnimalsBiological Specimen BanksCalciumCryopreservationEnergy MetabolismHEK293 CellsKidney TubulesMicePatents as TopicSubcellular FractionsCalciumcryopreservation of mitochondriamitochondria isolationmitochondria transplantation

Identifiers

PMID42505388
PMCPMC13406654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.