ArticleCells2026
Mesenchymal Stem Cells of Epicardial Adipose Tissue Show Differences in Immunophenotype and Osteogenic Potential in Patients with Coronary and Non-Coronary Heart Disease.
Olga V Gruzdeva, Tamara A Slesareva, Evgeniya E Gorbatovskaya, Sofia E Dolmatova, Yulia A Dyleva, Elena V Fanaskova, Alexander N Kokov, Asliddin B Nishonov, Olga L Barbarash
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Olga V GruzdevaFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.
Tamara A SlesarevaFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.
Evgeniya E GorbatovskayaFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.ORCID 0000-0002-0500-2449 Sofia E DolmatovaFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.
Yulia A DylevaFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.ORCID 0000-0002-6890-3287 Elena V FanaskovaFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.
Alexander N KokovFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.
Asliddin B NishonovFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.ORCID 0000-0002-9732-8218 Olga L BarbarashFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, 6, boulevard named after academician L.S. Barbarasha, Kemerovo 650002, Russia.ORCID 0000-0001-6981-9661 Funding
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences 0419-2022-0002
6 · The paper itselfAbstract
Coronary artery calcification (CAC) is a pressing issue in cardiology. Mesenchymal stem cells (MSCs) derived from epicardial adipose tissue (EAT) may serve as a source of osteoblasts in the cardiovascular system. This study aimed to evaluate and compare the immunophenotype, proliferation, and osteogenic potential of EAT-MSCs from patients with coronary artery disease (CAD) and those with aortic stenosis (AS). The immunophenotype of MSCs was analyzed based on key markers: CD105, CD90, CD73, CD31, CD34, CD45, HLA-DR. Cell proliferation was assessed by the doubling time of the population and the specific growth rate of the cultures. The osteogenic potential was evaluated by the expression levels of the
Indexed as
Adipose TissueCoronary Artery DiseaseEpicardial Adipose TissueImmunophenotypingMesenchymal Stem CellsOsteogenesisPericardiumAgedAortic Valve StenosisCell DifferentiationCell ProliferationFemaleHumansMaleMiddle Agedaortic stenosiscoronary artery calcificationepicardial adipose tissueischemic heart diseasemesenchymal stem cells
Identifiers
PMID42505380
PMCPMC13407134
What OpenQuestion holds
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