Transcriptome Changes Driving Multiple Regulatory Pathways Involved in TGF-β-Induced Anterior Subcapsular Cataract.

Sarah Y Coomson, Chirag Parsania, Charles G Bailey, Cynthia Metierre, Mary Flokis, Salil A Lachke, Frank J Lovicu

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah Y CoomsonDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0009-0004-6023-0235

Chirag ParsaniaCancer & Gene Regulation Laboratory, Centenary Institute, Sydney, NSW 2006, Australia.ORCID 0000-0003-4873-2385

Charles G BaileyCancer & Gene Regulation Laboratory, Centenary Institute, Sydney, NSW 2006, Australia.ORCID 0000-0002-4725-7829

Cynthia MetierreCancer & Gene Regulation Laboratory, Centenary Institute, Sydney, NSW 2006, Australia.

Mary FlokisSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-1328-4511

Salil A LachkeDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0001-8845-010X

Frank J LovicuSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-5492-9200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transforming Growth Factor-beta (TGF-β) promotes lens epithelial-mesenchymal transition (EMT) and fibrosis, contributing to anterior subcapsular cataract (ASC) formation. Transgenic mice overexpressing

Indexed as

CataractTranscriptomeTransforming Growth Factor betaTransforming Growth Factor beta1AnimalsEpithelial-Mesenchymal TransitionGene Expression ProfilingHumansLens, CrystallineMiceMice, TransgenicSignal TransductionTransforming Growth Factor betaTransforming Growth Factor beta1cataractendoplasmic reticulum (ER) stressepithelial–mesenchymal transition (EMT)epitheliumlensTGF-β1transcriptome

Identifiers

PMID42505373

DOI10.3390/cells15141263

PMCPMC13406664

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.