Evidence map›Paper›PMID 42505368›Full record

ArticleCells2026

Changes in the Adrenal Cortex Induced by Liraglutide Treatment and Exercise in a Rat Model of Menopausal Transition.

Ivona Gizdović, Branka Šošić-Jurjević, Dragana Vlahović, Nataša Ristić, Irena Lavrnja, Branko Filipović, Ljiljana Marina, Svetlana Trifunović

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ivona GizdovićInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0009-0004-6237-4021
Branka Šošić-JurjevićInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0002-5496-0619
Dragana VlahovićInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.
Nataša RistićInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0003-0994-1280
Irena LavrnjaInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0002-0607-5594
Branko FilipovićInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0001-5352-763X
Ljiljana MarinaCenter for Infertility and Endocrinology of Gender, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-2664-3664
Svetlana TrifunovićInstitute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0002-9141-5732

Funding

Ministry of Science, Technological Development, and Innovation 451-03-136/2025-03/200007
6 · The paper itself

Abstract

The menopausal transition is a key period marked by changes in cardiometabolic health and adrenal function, representing an important window for targeted interventions to improve women's health. Glucagon-like peptide-1 receptor agonists improve metabolic parameters, while physical exercise provides well-established benefits; however, their effects during the menopausal transition remain insufficiently explored. This study examined the effects of liraglutide (0.186 mg/kg; corresponding to the human equivalent dose of 1.8 mg/day used for type 2 diabetes treatment) and exercise on the adrenal gland in a rat model of menopausal transition. Three-month-old females served as young controls (CY), while 16-month-old acyclic females were assigned to control (C), liraglutide (L), exercise (E), or combined treatment (L+E). Compared with CY, the C group showed increased body mass and adrenal alterations, including reduced adrenal weight and volume, cortical atrophy, increased collagen content, decreased STAR, and increased pAMPKα optical density (

Indexed as

Adrenal CortexLiraglutideMenopausePhysical Conditioning, AnimalAldosteroneAnimalsBody WeightDisease Models, AnimalFemaleRatsRats, Sprague-DawleyAldosteroneLiraglutideacyclic female ratsadrenal glandexerciseliraglutide

Identifiers

PMID42505368
PMCPMC13406854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.