In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Andrzej WasilewskiStudent Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, ul. M. Skłodowskiej-Curie 48/50, 59-369 Wroclaw, Poland.ORCID 0000-0001-9908-6921 Hanna Czapor-IrzabekLaboratory of Elemental Analysis and Structural Research, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Milena ŚciskalskaDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.ORCID 0000-0001-8976-6683 Adam El IdrissiDepartment of Animal Science, Food and Nutrition (DiANA), Università Cattolica del Sacro Cuore, Via Emilia Parmense, 84, 29122 Piacenza, PC, Italy.ORCID 0009-0007-9968-0948 Fatima ChegdaniLaboratory of Integrative Biology, Department of Biology, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Route El Jadida, BP 5366 Maarif, Casablanca 20100, Morocco.ORCID 0000-0002-2473-0302 Agnieszka Matera-WitkiewiczScreening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.ORCID 0000-0002-1064-1237 Tomasz ZatońskiDepartment and Clinic of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.ORCID 0000-0003-3043-4806 Katarzyna Połtyn-ZaradnaDepartment of Social Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland.
Tomasz BrutkowskiDepartment of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland.
Aleksandra KlimczakLaboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland.ORCID 0000-0001-6590-4420 Bernarda KazanowskaDepartment of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland.
Agata SerrafiDivision of Medical Biochemistry, Department of Biochemistry and Immunochemistry, Faculty of Medicine, Wroclaw Medical University, ul. Chałubińskiego 10, 50-369 Wroclaw, Poland.ORCID 0000-0002-2826-6623 Funding
National Science Centre MINI.A070.22.004Wroclaw Medical University SUBK.A410.26.021
6 · The paper itselfAbstract
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and is associated with profound metabolic reprogramming. This exploratory study aimed to characterize the metabolomic profiles of plasma and cerebrospinal fluid (CSF) in children with newly diagnosed pre-B-cell acute lymphoblastic leukemia (pre-B ALL) prior to therapy. Metabolomic analyses were performed using mass spectrometry-based platforms combined with multivariate statistical approaches (PCA, OPLS-DA, SVM-RFE, EBAM). In plasma, we identified 41 significantly altered metabolites (FDR < 0.011), revealing a distinct signature that differentiated pre-B ALL patients from healthy controls. Specifically, patients exhibited elevated levels of hypoxanthine, xanthine, and phosphatidylcholine derivatives, alongside reduced concentrations of
Indexed as
MetabolomeMetabolomicsPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentChildChild, PreschoolFemaleHumansMalePilot ProjectsPurinesPurinesacute lymphoblastic leukemiamass spectrometrymetabolic profilingmetabolomicspediatric oncology
Identifiers
PMID42505365
PMCPMC13406799
What OpenQuestion holds
Textmetadata
LicenceCC BY
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