Evidence map›Paper›PMID 42505359›Full record

ArticleCells2026

Preclinical Evaluation of Human Donor-Derived Micronized Bone Marrow Stroma/Parenchyma Versus Bone Marrow Aspirate Concentrate in a Rat Model of Post-Traumatic Knee Osteoarthritis.

Haruki Nishimura, Zuokui Xiao, Jacob Singer, Xueqin Gao, William Sealy Hambright, Ryan Dregalla, Christopher T Donner, Lucanus S Koldewyn, Edward Jeffrey Donner, Johnny Huard

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haruki NishimuraThe Steadman Philippon Research Institute, Vail, CO 81657, USA.ORCID 0000-0002-5070-1185
Zuokui XiaoThe Steadman Philippon Research Institute, Vail, CO 81657, USA.
Jacob SingerThe Steadman Philippon Research Institute, Vail, CO 81657, USA.
Xueqin GaoThe Steadman Philippon Research Institute, Vail, CO 81657, USA.ORCID 0000-0001-5833-1548
William Sealy HambrightBMAX Medical LLC, Johnstown, CO 80534, USA.ORCID 0009-0000-8496-1746
Ryan DregallaBMAX Medical LLC, Johnstown, CO 80534, USA.ORCID 0000-0002-7516-4849
Christopher T DonnerBMAX Medical LLC, Johnstown, CO 80534, USA.ORCID 0009-0001-5611-8791
Lucanus S KoldewynBMAX Medical LLC, Johnstown, CO 80534, USA.
Edward Jeffrey DonnerBMAX Medical LLC, Johnstown, CO 80534, USA.ORCID 0000-0002-9872-8758
Johnny HuardThe Steadman Philippon Research Institute, Vail, CO 81657, USA.

Funding

Colorado Office of Economic Development and International Trade stem cell banking grant
6 · The paper itself

Abstract

Bone marrow aspirate concentrate (BMAC) is widely used as a source of mesenchymal stromal/stem cells (MSCs) for musculoskeletal regeneration; however, BMAC lacks essential bone marrow extracellular matrix (ECM) components, a critical component of the stem cell niche that regulates MSC survival, paracrine signaling, and regenerative capacity. We previously demonstrated that an ECM-retaining micronized bone marrow product (BMAX™) preserves pro-regenerative MSC phenotypes in vitro. Human bone marrow from a single donor was processed into conventional BMAC or BMAX™. Post-traumatic osteoarthritis was induced in immunodeficient rats using destabilization of the medial meniscus (DMM). Four weeks after surgery, animals were randomly assigned to receive intra-articular injections of BMAX™, BMAC, or phosphate-buffered saline (

Indexed as

Bone MarrowBone Marrow CellsMesenchymal Stem CellsOsteoarthritis, KneeTissue DonorsAnimalsBone Marrow TransplantationDisease Models, AnimalHumansMaleMesenchymal Stem Cell TransplantationRatsX-Ray Microtomographybone marrow nicheextracellular matrixmesenchymal stromal cellsorthobiologicsosteoarthritis

Identifiers

PMID42505359
PMCPMC13407337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.