Evidence map›Paper›PMID 42505297›Full record

ArticleGels (Basel, Switzerland)2026

Reduction-Responsive Boc-Modified Gelatin-Based Hydrogels for Enhanced Hydrophobic Drug Loading and Controlled Release.

Shuo Wang, Ruxin Zhang, Xiangyu Chen, Helong Wang, Yingfei Hu, Yuanxi Zhu, Wenhui Lu, Deyi Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuo WangState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Ruxin ZhangState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Xiangyu ChenState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Helong WangState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Yingfei HuState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Yuanxi ZhuState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Wenhui LuState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.ORCID 0000-0002-8047-821X
Deyi ZhuState Key Laboratory of Green Papermaking and Resource Recycling, Faculty of Light Industry, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.ORCID 0000-0002-2986-3964

Funding

Major Scientific Research Project for the Construction of State Key Lab 2025ZDGZ02the 2025 Jinan City-University Integration Project for Sci-Tech Achievement Transformation 202534065
6 · The paper itself

Abstract

Conventional gelatin-based hydrogels lack responsiveness to the tumor microenvironment and exhibit low drug-loading efficiency for hydrophobic drugs, which limits their application in targeted cancer therapy. In this study, a reduction-responsive gelatin hydrogel was developed by grafting hydrophobic tert-butoxycarbonyl (Boc) groups onto gelatin chains, followed by EDC/NHS-mediated chemical cross-linking with L-cysteine dimethyl ester dihydrochloride, which contains disulfide bonds. The success of Boc grafting was confirmed by

Indexed as

Boc modificationdrug controlled releasegelatin-based hydrogelhydrophobic drug deliveryreduction-responsive

Identifiers

PMID42505297
PMCPMC13409542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.