ReviewGels (Basel, Switzerland)2026
Research Progress on Natural Polysaccharide Hydrogels in the Diagnosis and Treatment of Colorectal Cancer.
Review in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Colorectal Cancer (CRC) is a prevalent global malignant tumor, and conventional therapies and drugs for CRC are limited by poor targeting and severe toxic side effects. Existing reviews on hydrogel-based CRC treatments mainly focus on synthetic materials or single-responsive systems concerning drug loading and local delivery. Natural polysaccharides possess inherent anti-inflammatory, antioxidant and antitumor activities, and polysaccharide hydrogels (PSHs) prepared from them exhibit favorable biocompatibility, tunable structures and potential targeting capability, which can synergistically enhance the efficacy of loaded drugs and thus become a research hotspot. This article summarizes the pathogenesis and conventional treatments of CRC, introduces monocomponent and composite PSHs as well as physical and chemical crosslinking methods, and emphasizes their tumor microenvironment (TME)-responsive mechanisms, combined drug effects and clinical applications. It also analyzes the challenges in safety evaluation and practical application, and summarizes recent advances in the use of artificial intelligence (AI) for PSHs design, regulation, performance prediction and implementation. This paper serves as a reference for follow-up research and clinical translation of hydrogels prepared from natural polysaccharides for the treatment of CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.