Evidence map›Paper›PMID 42505274›Full record

ArticleGels (Basel, Switzerland)2026

Storage and Stability of AAV-Containing Fibrin Hydrogels for Retinal Gene Therapy.

Aubrey Berger, Travis Knudsen, Francesca Kopp, David Korda, Mary Lang, Brittni A Scruggs, Alan D Marmorstein

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aubrey BergerBiomedical Graduate Program, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0005-1913-3502
Travis KnudsenDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
Francesca KoppDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
David KordaDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0009-0000-8384-2104
Mary LangDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-0895-0903
Brittni A ScruggsDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
Alan D MarmorsteinDepartment of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-0363-2399

Funding

Goldman Philanthropic Partnerships noneMayo Clinic none
6 · The paper itself

Abstract

Subretinal and intravitreal injection of retinal gene therapy is associated with serious adverse events and poor efficacy. We sought to improve retinal gene therapy delivery by developing fibrin hydrogel encapsulated adeno-associated virus (FE-AAV). Here we investigate conditions for storage and stability for FE-AAV. FE-AAV containing 1.9 × 10

Indexed as

AAVgene therapyhydrogelretinal diseasestabilitystorage

Identifiers

PMID42505274
PMCPMC13409518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.