Chitosan-Based Adhesive Composite Hydrogel to Provide Antibacterial and Anti-Inflammatory Properties for Biomedical Application.

Sinuo Yan, Jingna Xu, Yue Shen, Chengde Liu, Xigao Jian, Zhonghai Li

Abstract read

In one paragraph

Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sinuo YanDalian Medical University, Dalian 116044, China.

Jingna XuDepartment of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China.

Yue ShenDepartment of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China.

Chengde LiuDepartment of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China.

Xigao JianDepartment of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China.

Zhonghai LiDalian Medical University, Dalian 116044, China.

Funding

Sinopec Research Fund 225061the Key Research and Development Program of Liaoning Provincial Department of Education 2024C011the Key Research and Development Project of the Liaoning Provincial Science and Technology Joint Program 2025JH2/101800040

6 · The paper itself

Abstract

Hydrogel dressings are critical in biomedical applications. However, developing multifunctional hydrogel dressings that combine antibacterial action, strong interfacial adhesion, and anti-inflammatory regulation remains a significant challenge. This study presents a novel chitosan-EMA-DMA hydrogel consisting of MgO and chitosan-curcumin nanoparticles. DMA endowed the hydrogel with adhesive performance, and EMA with water sorption enhanced the swelling ratio of the hydrogel which could control the release of the functional ingredient. The multifunctional composite hydrogel containing MgO and Curcumin demonstrated antibacterial activity and inflammatory regulation. The findings from the Fourier transform infrared spectrometer (FTIR), NMR, and SEM confirmed the successful material synthesis and the preparation of the composite hydrogel. The swelling ratio was enhanced by 50% after EMA was introduced. The adhesive strength of the composite hydrogel with skin tissue was enhanced to 90 kPa due to the introduction of DMA. The antibacterial study showed that Mg released from the multifunctional composite hydrogel enhanced the antibacterial efficacy of the composite hydrogel against

Indexed as

adhesiveantibacterialanti-inflammationcomposite hydrogel

Identifiers

PMID42505263

DOI10.3390/gels12070580

PMCPMC13409680

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.