Evidence map›Paper›PMID 42505262›Full record

ReviewGels (Basel, Switzerland)2026

Biomedical Hydrogels Based on Natural Polysaccharides: Structural Design.

Zezheng Liu, Xin Huang, Jinjin Tong, Hua Zhang

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zezheng LiuCollege of Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, China.ORCID 0000-0002-5757-6356
Xin HuangCollege of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China.
Jinjin TongCollege of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China.
Hua ZhangCollege of Veterinary Medicine, Beijing University of Agriculture, Beijing 102206, China.

Funding

National Natural Science Foundation of China No.32272904National Natural Science Foundation of China No.32373086
6 · The paper itself

Abstract

Hydrogels have gained prominence as a class of biomaterials in biomedicine due to their excellent biocompatibility, biodegradability, and high water retention. Among them, hydrogels derived from natural polysaccharides sourced from plants, animals, and microbes are attracting growing interest due to their renewable nature, low toxicity, low immunogenicity, and diverse functional properties. While several recent reviews have addressed polysaccharide-based hydrogels, they have largely focused on isolated aspects-such as 3D bioprinting formulations, double-network mechanical reinforcement, rheological behavior, or single-source polysaccharides-without establishing an integrated framework that links raw material selection, structural diversity, chemical modification, and crosslinking design to clinical translation. This review distinguishes itself by providing a systematic, end-to-end perspective that spans from the structural diversity of plant- and microbe-derived polysaccharides through recent advances in chemical modification and novel cross-linking strategies, to the fine-tuning of physicochemical properties for enhanced therapeutic outcomes. This article provides an overview of the progress made in the emerging biomedical applications and material design of natural polysaccharide hydrogels in terms of raw material selection, chemical modification, cross-linking mechanisms, and functional utilization. It aims to fully explore the potential of these materials and promote integration into advanced biomedical practices.

Indexed as

biomedical hydrogelcross-linking methodnatural polysaccharidetissue engineering and regenerative medicine

Identifiers

PMID42505262
PMCPMC13408715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.