Evidence map›Paper›PMID 42505217›Full record

ArticleCurrent oncology (Toronto, Ont.)2026

Assessing Immune Fitness in Oncological Rehabilitation-Validity and Responsiveness of the Immune Status Questionnaire and Single-Item Scale.

Anne M S de Hoop, Johanna A Eggink, Cindy Veenhof, Cyrille A M Krul, Jelle P Ruurda, Raymond H H Pieters, Karin Valkenet

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Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Anne M S de HoopResearch Group Innovation of Human Movement Care, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3583CS Utrecht, The Netherlands.ORCID 0000-0001-6831-934X
Johanna A EgginkResearch Group Innovation of Human Movement Care, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3583CS Utrecht, The Netherlands.
Cindy VeenhofResearch Group Innovation of Human Movement Care, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3583CS Utrecht, The Netherlands.
Cyrille A M KrulResearch Group Innovative Testing in Life Sciences and Chemistry, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3583CS Utrecht, The Netherlands.
Jelle P RuurdaDepartment of Surgery, University Medical Center Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.ORCID 0000-0001-6584-1677
Raymond H H PietersResearch Group Innovative Testing in Life Sciences and Chemistry, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3583CS Utrecht, The Netherlands.ORCID 0000-0002-3427-8401
Karin ValkenetResearch Group Innovation of Human Movement Care, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3583CS Utrecht, The Netherlands.ORCID 0000-0002-4715-685X

Funding

Regieorgaan SIA KIEM.K23.01.077
6 · The paper itself

Abstract

backgroundImmune fitness (IF) reflects the body's ability to mount appropriate immune responses. Monitoring IF could improve tailored treatment in oncological rehabilitation. The Immune Status Questionnaire (ISQ) and the Single-Item Scale (SIS) were developed to assess IF, but their clinimetric properties in cancer rehabilitation remain unknown.

aimsTo evaluate the construct validity, responsiveness, and correlation between the ISQ and the SIS in oncological rehabilitation.

methodsThe study population included people participating in oncological rehabilitation during or within one year after medical treatment. Data were collected prospectively via questionnaires. Construct validity and responsiveness were assessed through predefined hypotheses, including correlations with fatigue, sleep problems, malnutrition risk, activity impairment, and physical functioning.

resultsIn total, 97 individuals were included in the analyses. Median ISQ and SIS scores were 8/10 and 7/10, respectively. Correlations ranged from r = -0.21 to r = -0.50. Only the SIS correlations with fatigue and physical functioning, and the ISQ correlation with fatigue, met the predefined thresholds. Responsiveness hypotheses were not confirmed.

conclusionsThe ISQ and the SIS demonstrated low construct validity and responsiveness in this population. IF scores were higher than expected. Correlations showed links between fatigue, physical functioning, and IF. Future research should develop tools tailored to the complex immune disturbances experienced by cancer survivors.

Indexed as

NeoplasmsAdultAgedFatigueFemaleHumansMaleMiddle AgedSurveys and Questionnairescancerimmune fitnessimmune systemphysical therapy

Identifiers

PMID42505217
PMCPMC13409571

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