Evidence map›Paper›PMID 42505123›Full record

ArticlemSystems2026

Population-level genome sequencing reveals distinct

Michael C Chao, Michael R Chase, Shoko Wakabayashi, Andrew J Vickers, Byron Roman, Forrest Hopkins, Peter H Culviner, Maximillian G Marin, Pauline Maiello, Collin R Diedrich and 4 more

Abstract read
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Michael C ChaoDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-3158-7337
Michael R ChaseDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-9789-0542
Shoko WakabayashiDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Andrew J VickersDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Byron RomanDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Forrest HopkinsDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-3801-4673
Peter H CulvinerDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-0605-5849
Maximillian G MarinDepartment of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0002-9108-3328
Pauline MaielloDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Collin R DiedrichCenter for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zandrea AmbroseDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8610-2766
Philana Ling LinCenter for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-5169-3714
Qingyun LiuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0002-2284-5050
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-7565-9975

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)75N93019C00071 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FORTUNE, SARAH · 2019 to 2025
$57.3M
Influence of SIV replication on TB progression and immunityR01AI134195 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSE, ZANDREA, LIN, PHILANA LING · 2017 to 2021
$4.8M
National Institute of Allergy and Infectious Diseases 75N93019C00071, R01AI134195NIAID NIH HHS R01 AI134195NIH HHS 75N93019C00071
6 · The paper itself

Abstract

Whole-genome sequencing of IMPORTANCE: Tuberculosis (TB) remains a leading cause of death worldwide, especially in people living with HIV (PLHIV). How HIV infection and antiretroviral therapy impact

Indexed as

Anti-Retroviral AgentsCoinfectionMutationMycobacterium tuberculosisSimian Acquired Immunodeficiency SyndromeTuberculosisAnimalsGenome, BacterialHIV InfectionsHumansMacaca mulattaSimian Immunodeficiency VirusWhole Genome SequencingAnti-Retroviral Agentsantiretroviral agentsdisseminationDNA sequencingevolutionMycobacterium tuberculosisnon-human primatepathogenesissimian immunodeficiency virustuberculosis

Identifiers

PMID42505123
PMCPMC13487684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.