Evidence map›Paper›PMID 42505121›Full record

ArticleJournal of virology2026

Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates.

Hannah A D King, Caroline Subra, Emily Tourtellott, Isabella Swafford, Shraddha Basu, Matthew Rossman, Lana Phillips, Nyerhovwo Obarorakpor, Shilei Ding, Maria Grazia Ferrari and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Hannah A D King *U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Caroline Subra *U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0001-5272-0972
Emily TourtellottU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Isabella SwaffordU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Shraddha BasuU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Matthew RossmanU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Lana PhillipsU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Nyerhovwo ObarorakporU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Shilei DingCentre de Recherche du CHUM, Montreal, Quebec, Canada.
Maria Grazia FerrariBIOQUAL, Inc., Rockville, Maryland, USA.
Zoltan BeckU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Eric LewitusU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Hongjun BaiU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Ming DongU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Bonnie M SlikeU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Dohoon KimU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Vincent DussuptU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Letzibeth Mendez-RiveraU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Nathan EiselCenter for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
Lu ZhangCenter for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
LaTonya D WilliamsCenter for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
Georgia D TomarasCenter for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-8076-1931
Andrés FinziCentre de Recherche du CHUM, Montreal, Quebec, Canada.ORCID 0000-0002-4992-5288
Gary R MatyasU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0002-2074-2373
Shelly J KrebsU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0003-1136-1760
Morgane RollandU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0003-3650-8490
Mangala RaoU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Dominic Paquin-ProulxU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Diane L BoltonU.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0003-1897-499X

Funding

Structure-Function Analytics CoreP01AI162242 · NIAID · DUKE UNIVERSITY · PI TOMARAS, GEORGIA DORIS · 2021 to 2025
$22.2M
NIAID NIH HHS P01 AI162242
6 · The paper itself

Abstract

To identify strategies for augmenting vaccine immunogenicity, we compared a pox-protein prime-boost regimen comprising recombinant modified vaccinia virus Ankara and multimeric HIV-1 Env gp145, adjuvanted with Army Liposomal Formulation (ALF) either adsorbed to aluminum salt (ALFA) or formulated with the QS-21 saponin (ALFQ), in rhesus macaques. ALFQ promoted greater magnitude and more durable humoral and cellular immune responses than ALFA, which exhibits similar immunogenicity to aluminum-based adjuvants. Peak Env-specific CD4

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineAIDS VaccinesHIV-1HIV InfectionsAnimalsAntibodies, NeutralizingCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesenv Gene Products, Human Immunodeficiency VirusGenetic VectorsHIV AntibodiesImmunity, CellularImmunization, SecondaryLiposomesAdjuvants, ImmunologicAdjuvants, VaccineAIDS VaccinesAntibodies, NeutralizingCytokinesenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesLiposomessaponin QA-21V1SaponinsALFAALFQ adjuvantsCD8+ T cell responseHIV-1 vaccineimmune response boostingnext-generation liposomal adjuvantpox viral vectorrhesus macaqueSHIV challenge

Identifiers

PMID42505121
PMCPMC13483363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.