Evidence map›Paper›PMID 42505091›Full record

ArticlemBio2026

Itaconate negatively regulates innate immunity during fungal pneumonia.

Thomas Draper, Pari Dhruva, MaryJane Jones, Rachel McCarley, Christine M Bojanowski, Chad Steele

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas DraperDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.ORCID 0009-0004-4233-3708
Pari DhruvaDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
MaryJane JonesDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Rachel McCarleyDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Christine M BojanowskiDepartment of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Chad SteeleDepartment of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0001-5655-4596

Funding

Immunopathogenesis in fungal asthmaR01HL122426 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Chad Steele · 2015 to 2026
$5.1M
Biology of innate IL-22 during lung fungal infectionR01HL136211 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEELE, CHAD · 2017 to 2024
$3.0M
NHLBI NIH HHS R01 HL122426NHLBI NIH HHS R01 HL136211NIH HHS HL122426, HL136211
6 · The paper itself

Abstract

The innate immune response to pathogens often involves metabolic reprogramming, such as disruption of the Krebs cycle, leading to the accumulation of various metabolites that can further influence innate cell responses during infection. Of these, the immunomodulatory metabolite itaconate has been shown to positively or negatively influence lung immune responses, depending on the pathogen. In the current study, we found that mice deficient in aconitate decarboxylase (

Indexed as

Aspergillus fumigatusImmunity, InnatePneumoniaSuccinatesAnimalsCarboxy-LyasesHydro-LyasesLungMacrophages, AlveolarMiceMice, Inbred C57BLMice, KnockoutNeutrophilsAcod1 protein, mouseaconitate decarboxylaseCarboxy-LyasesHydro-Lyasesitaconic acidSuccinatesfungalinnate immunitylung defense

Identifiers

PMID42505091
PMCPMC13463890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.