Evidence map›Paper›PMID 42505077›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions.

Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Qing ZhangChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Dashu LiNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Bo LiuDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Yue ZhangPuensum Genetech Institute, Wuhan, China.
Min LiPuensum Genetech Institute, Wuhan, China.
Ruochun GuoCenter For Microbiome Medicine, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yawen NiNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Shibin ChenNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Biao NiDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Lijie QiuDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Guorui XingPuensum Genetech Institute, Wuhan, China.
He DongSchool of Mathematics and Statistics, Changchun University of Technology, Changchun, China.
Qiulong YanCenter For Microbiome Medicine, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2697-4562
Shenghui LiPuensum Genetech Institute, Wuhan, China.
Xiaohui ZouNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-0607-4759
Bin CaoNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Funding

Beijing Research Ward Excellence Program BRWEP2024W114060104National High Level Hospital Clinical Research Funding 025-NHLHCRF-JBGS-B-WZ-06National Key R&D Program of China 2022YFA1304303National Natural Science Foundation of China 82341113
6 · The paper itself

Abstract

The respiratory microbiota is a critical determinant of airway health, yet functional characterization remains challenging due to the lack of a high-resolution reference catalog. To address this gap and enable systematic investigation at both species and gene levels, we constructed the integrated Human Airway Microbiome Gene Catalog (iHAMGC) through high-throughput metagenomic analysis of 12,273 airway samples. This catalog comprises 24,185,985 non-redundant microbial genes and provides extensive taxonomic and functional annotations, with a particular focus on clinically relevant elements, including antibiotic resistance genes, virulence factors, and antimicrobial peptides. We further resolved the bacterial hosts of resistance genes and virulence factor genes, as well as taxa contributing to antimicrobial peptide activity. The iHAMGC captures site-specific microbial and functional variations across distinct airway niches and reveals regional differences in functional potential. By offering a comprehensive, publicly accessible reference for airway microbial genes, the iHAMGC serves as a foundational resource for advancing our understanding of the airway microbiota in respiratory health and disease.

Indexed as

antibiotic resistance genesantimicrobial peptidesgene cataloghuman airway microbiotavirulence factor genes

Identifiers

PMID42505077
PMCPMC13403716

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.