Evidence map›Paper›PMID 42505053›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds.

Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiang ZhengCollege of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, People's Republic of China.
Mingmei LiState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
Jianjun JiangState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
Yongchao WangSchool of Life Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.ORCID https://orcid.org/0000-0001-8152-2350
Yaru JiaCollege of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, People's Republic of China.
Weilun SunCAS Key laboratory for Biomedical effects of nanomaterials and nanosafety, CAScenter for excellence in nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.
Yi YaoState Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Pengli GaoState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
Linhua ZhangState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
Qi GuoCollege of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, People's Republic of China.
Guang JiaCollege of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, People's Republic of China.
Xing-Jie LiangCAS Key laboratory for Biomedical effects of nanomaterials and nanosafety, CAScenter for excellence in nanoscience, National Center for Nanoscience and Technology of China, Beijing, People's Republic of China.ORCID https://orcid.org/0000-0002-4793-1705
Dunwan ZhuState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.
Jinchao ZhangCollege of Chemistry & Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, People's Republic of China.ORCID https://orcid.org/0000-0002-5279-0468
Fangzhou LiState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People's Republic of China.

Funding

China Association for Science and Technology 2024-2026QNRC001China Postdoctoral Science Foundation 2025M772903China Postdoctoral Science Foundation GZC20251910Chinese Academy of Medical Sciences 2023-I2M-2-008Chinese Academy of Medical Sciences 2024-I2M-3-007Chinese Academy of Medical Sciences (Non-profit Central Research Institute Fund 2025-JKCS-16Hebei Natural Science Foundation B2025201113National Natural Science Foundation of China 22506216National Natural Science Foundation of China 32571613National Natural Science Foundation of China U25A20148Tianjin Natural Science Foundation 25JCZDJC00350
6 · The paper itself

Abstract

Diabetic wound healing is critically impaired by a pathological microenvironment with two core barriers: circulatory deficits from microangiopathy, and a loss of nanoscale topographical guidance due to extracellular matrix (ECM) disruption. To address this, we developed Musc@CP, an advanced dressing that synergistically combines an ECM-mimetic multi-property scaffold with active vascular modulation. The platform is based on a chitosan-pullulan (CP) nanofibrous scaffold that structurally recapitulates healthy dermal ECM to direct fibroblast adhesion and migration. The matrix incorporates muscone (Musc), a bioactive compound that attenuates intracellular Ca

Indexed as

diabetic wound healingextracellular matriximmune microenvironmentnanofibrous scaffoldperfusion

Identifiers

PMID42505053
PMCPMC13403889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.