Evidence map›Paper›PMID 42505047›Full record

ReviewCell biology international2026

Probing Centromere Plasticity and Chromatin Remodeling Using Single-Molecule Techniques.

Ran Liu, Jiayi Zhao, Hongfei Ma, Wenping Hu, Zhen Dou, Xing Liu

Abstract readReview
In one paragraph

Review in Cell biology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ran LiuMOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China School of Life Sciences, Hefei, China.
Jiayi ZhaoMOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China School of Life Sciences, Hefei, China.
Hongfei MaMOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China School of Life Sciences, Hefei, China.
Wenping HuMOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China School of Life Sciences, Hefei, China.
Zhen DouMOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China School of Life Sciences, Hefei, China.
Xing LiuMOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China School of Life Sciences, Hefei, China.ORCID https://orcid.org/0000-0002-7480-5085

Funding

Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China JYB2025XDXM505MOST-NSFC 2022YFA0806800MOST-NSFC 2022YFA1303100MOST-NSFC 32450537MOST-NSFC 32470779MOST-NSFC 32521003MOST-NSFC W2411017Plans for Major Provincial Science & Technology Projects of Anhui Province 202303a07020003
6 · The paper itself

Abstract

The centromere functions as an essential interactive hub for mediating the equal distribution of sister chromatids during eukaryotic cell division and is subject to cell cycle-specific plasticity regulation. To ensure the replication, transcription, and repair of genetic information, chromatin remodeling is an indispensable molecular biology event. Both centromere plasticity and chromatin remodeling involve numerous protein components (e.g., Constitutive Centromere-Associated Network (CCAN), SWItch/Sucrose Non-Fermentable (SWI/SNF)) and exhibit highly dynamic spatiotemporal regulation, posing significant challenges for traditional ensemble approaches in elucidating their detailed mechanisms. In recent years, single-molecule techniques have revolutionized the study of chromatin remodeling and kinetochore assembly. By capturing real-time, high-resolution dynamics of molecular interactions, these methods uncover mechanistic insights inaccessible to conventional approaches. This review summarizes key advances and emerging paradigms enabled by single-molecule analysis tools, highlighting how they are reshaping our understanding of the mechanism of mitotic fidelity and epigenetic regulation, and providing a roadmap for future research in these fields.

Indexed as

CentromereChromatin Assembly and DisassemblySingle Molecule ImagingAnimalsChromatinChromosomal Proteins, Non-HistoneEpigenesis, GeneticHumansKinetochoresChromatinChromosomal Proteins, Non-Histonecentromerechromatin remodelingkinetochore assemblysingle‐molecule techniques

Identifiers

PMID42505047
PMCPMC13403610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.