ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Polychip-A High-Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman and 2 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Adrian Ryan GuzmanDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, USA.
Aifen ZhouDepartment of Chemical Engineering, Texas A&M University, College Station, USA.
Han ZhangDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, USA.
Rohit GupteDepartment of Biomedical Engineering, Texas A&M University, College Station, USA.
Kaylee DelgadoDepartment of Microbial Pathogenesis and Immunology, Texas A&M University, College Station, USA.
Sini SkariahDepartment of Microbiology and Immunology, Weill Cornell Medicine - Qatar, Cornell University, Education City, Doha, Qatar.
Ali SultanDepartment of Microbiology and Immunology, Weill Cornell Medicine - Qatar, Cornell University, Education City, Doha, Qatar.
Arul JayaramanDepartment of Chemical Engineering, Texas A&M University, College Station, USA.
Paul de FigueiredoChristopher S. Bond Life Sciences Center, University of Missouri, Columbia, USA.
Funding
Development of a High-Throughput Microfluidics-Enabled Functional Assay for Rapidly Identifying Neutralizing AntibodiesR01AI141607 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI DE FIGUEIREDO, PAUL, HAN, ARUM · 2019 to 2023
$3.4MGUARD: A global unbiased antimicrobial discovery platformR01AI168685 · NIAID · TEXAS ENGINEERING EXPERIMENT STATION · PI ARUL JAYARAMAN · 2023 to 2026
$3.0MAccelerating discovery of neutralizing paratopes with Functional Antibody Screening TechnologyR21AI139738 · NIAID · TEXAS A&M UNIVERSITY · PI HAN, ARUM · 2020 to 2021
$415kDefense Advanced Research Projects Agency (DARPA) W911NF1920013,HR00112320006National Institute of Allergy and Infectious Diseases 1R01AI168685-01A1National Institute of Allergy and Infectious Diseases R01AI141607-01A1National Institute of Allergy and Infectious Diseases R21AI139738-01A1NIAID NIH HHS R01 AI141607NIAID NIH HHS R01 AI168685NIAID NIH HHS R21 AI139738NIH HHSQatar National Research Foundation NPRP9-001-2-001Texas A&M University Advancing Discovery to Market M2404535
6 · The paper itselfAbstract
Microbial interactions are fundamental to ecology, health, and disease, yet high-throughput tools to study these complex relationships remain scarce. We introduce Polychip, a fully integrated, high-throughput droplet microfluidics platform that revolutionizes microbial interaction screening. By seamlessly combining six microfluidic operations onto a single chip, Polychip achieves 99.7% efficiency and accelerates screening by 11-14 times compared to traditional high-throughput liquid handling robotic methods, with minimal human input. Using the Polychip, we screened 2.24 × 10
Indexed as
antimicrobial discoverydroplet microfluidicsenvironmental microorganismshigh‐throughput screeningpolymicrobial interactions
Identifiers
PMID42504986
PMCPMC13403381
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