Evidence map›Paper›PMID 42504943›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Single-Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei.

Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xi LiDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Lei WangLiangzhu Laboratory, Zhejiang University, Hangzhou, People's Republic of China.
Lei AiDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Zimeng LiDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Zhaochangci ChenDepartment of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yuchen LuoDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Tianran ZhangDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Mengjia LiaoDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Songhao WangDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Jiajia CuiNational Clinical Research Center for Geriatric Disorders, Changsha, Hunan, People's Republic of China.
Ke LiuNational Clinical Research Center for Geriatric Disorders, Changsha, Hunan, People's Republic of China.
Chengxian GuoCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Guodong LiuDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Jiye YinNational Clinical Research Center for Geriatric Disorders, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0000-0002-1244-5045
Wei WuDepartment of Geriatric Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Funding

Furong Laboratory Science and Technology Projects 2023SK2083-2Major Research Project for High-Level Health and Wellness Talents of Hunan Province R2023042National Natural Science Foundation of China 82073943National Natural Science Foundation of China 82204533National Natural Science Foundation of China 82370544National Natural Science Foundation of China 82373962National Natural Science Foundation of China 82404037National Natural Science Foundation of China 82450103National Natural Science Foundation of China 82570656National Natural Science Foundation of China 82574507Natural Science Foundation of Hunan Province 2023JJ30822Natural Science Foundation of Hunan Province 2023JJ40931Scientific Research Program of FuRong Laboratory 2025PT5001Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University YX202110
6 · The paper itself

Abstract

Pseudomyxoma peritonei (PMP) is characterized by progressive mucus accumulation, extensive stromal fibrosis, rare extraperitoneal metastasis, limited therapeutic options, and frequent recurrence. However, the microenvironmental ecosystem of PMP, particularly in metastatic lesions, remains poorly understood. Here, we integrated single-cell RNA sequencing, whole-exome sequencing, bulk RNA sequencing, and histopathologic validation to construct a high-resolution atlas of primary and paired metastatic tumors. Epithelial cells showed distinct functional states, including a TFF3

Indexed as

anti‐angiogenic therapyappendiceal mucinous neoplasmimmune exclusionlipid metabolismpseudomyxoma peritoneisingle‐cell RNA sequencingtumor microenvironment

Identifiers

PMID42504943
PMCPMC13403377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.