Evidence map›Paper›PMID 42504920›Full record

ReviewCNS neuroscience & therapeutics2026

Exercise, Demethylase FTO, Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms.

Yanan Zheng, Yili Zheng, Peijie Chen, Xueqiang Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanan ZhengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0001-9958-9844
Yili ZhengDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.ORCID 0000-0003-3154-9568
Peijie ChenDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, China.
Xueqiang WangDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0001-5577-5231

Funding

National Natural Science Foundation of China 82372578
6 · The paper itself

Abstract

MAIN PROBLEM AND

methodsThis review aims to summarize the role of fat mass and obesity-associated protein (FTO) in neurological disorders and neuropathic pain (NP).

resultsKey findings suggest that in neurological disorders such as Alzheimer's disease, Parkinson's disease, and depression, FTO-regulated m

conclusionsThis implies that exercise may serve as an effective intervention for modulating epigenetic modifications, potentially by downregulating the demethylase FTO, regulating m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOExerciseNervous System DiseasesNeuralgiaAnimalsHumansAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanexerciseFTON6‐methyladenosineneurological disordersneuropathic painreview

Identifiers

PMID42504920
PMCPMC13403481

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.