ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Time-Restricted Feeding With High-Fat Diet Slows Weight Gain and Reduces Renal Calcium Oxalate Crystal Formation Without Reducing Energy Intake.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Renal calcium oxalate stones are closely linked to lipid metabolism disorders. A long-term high-fat diet (HFD) can lead to obesity and other metabolic disorders, which significantly contribute to stone formation. Recent studies indicate that time-restricted feeding (TRF) plays a crucial role in improving metabolic homeostasis and preventing metabolic diseases. However, its impact on kidney stone formation has yet to be investigated. We examined differences in calcium oxalate crystal formation in mouse kidneys using glyoxylic acid (Gly) modeling in HFD mouse models subjected to either ad libitum (Ad) feeding or TRF. TRF mitigated weight gain, improved blood lipid metabolism disorders, and reduced lipid deposition in the liver and kidneys, alleviating pathological damage. Compared with the Ad group, the TRF group exhibited lower urinary concentrations of oxalate and calcium ions, which corresponded with reduced expression of OPN and CD44, leading to decreased oxalate crystal formation. Gly intervention in the Ad group increased the expression of TNF-α and IL-6 in the kidneys, leading to an imbalance between oxidative stress and antioxidant responses. In contrast, TRF showed significant improvement, potentially linked to activation of the PI3K-AKT pathway. Nighttime TRF, which more closely aligns with the natural work and rest rhythms of mice, produced more pronounced effects than daytime TRF. NR1D1 expression in the kidneys was closely associated with stone formation. TRF can improve lipid metabolism and inhibit the formation of renal calcium oxalate stones, and dietary preventive strategies that align with biological rhythms demonstrate particularly significant effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.