Evidence map›Paper›PMID 42504849›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Standardizing care for agitation in Alzheimer's disease, results from a randomized controlled trial of an integrated care pathway versus usual care - the StaN trial.

Sanjeev Kumar, Amer M Burhan, Sarah Colman, Li Chu, Simon Davies, Peter Derkach, Sarah Elmi, Philip Gerretsen, Ariel Graff-Guerrero, Kyle Greenway and 15 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sanjeev KumarDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-8115-353X
Amer M BurhanDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Sarah ColmanDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Li ChuDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Simon DaviesDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Peter DerkachWest Park Health Care Centre, Toronto, Ontario, Canada.
Sarah ElmiDepartment of Geriatric Psychiatry, Ontario Shores Centre for Mental Health Sciences, Whitby, Ontario, Canada.
Philip GerretsenDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ariel Graff-GuerreroDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kyle GreenwayDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada.
Maria HussainDepartment of Psychiatry, Queen's University, Kingston, Ontario, Canada.
Zahinoor IsmailDepartments of Psychiatry, Clinical Neurosciences, Community Health Sciences, and Pathology & Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Donna KimDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Linda KrismanDivision of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Clement MaDivision of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Rola MoghabghabDivision of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Benoit H MulsantDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Bruce G PollockDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Soham RejDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada.
Aviva RostasDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Nicole SchoerDivision of Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
David L StreinerDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
Lisa Van BusselDepartment of Psychiatry, Western University, London, Ontario, Canada.
Tarek K RajjiDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
StaN Study Group

Funding

Brain Canada Foundation through the Canada Brain Research FundCentre for Aging and Brain Health Innovation
6 · The paper itself

Abstract

backgroundAdherence to treatment guidelines for agitation in dementia is suboptimal and inconsistent. We designed and evaluated an Integrated Care Pathway (ICP) for the management of agitation in dementia.

methodsThis was a double-blind randomized controlled trial at 12 inpatient units and long-term-care homes (LTCHs) across Canada. Participants were randomized 1:1 to the ICP or treatment-as-usual (TAU). Primary outcomes were Cohen Mansfield Agitation Inventory (CMAI) and psychotropic polypharmacy at 12 weeks.

resultsWe randomized 185 participants (93 inpatients, 92 in LTCHs). For CMAI, there were no significant time-by-treatment-group interactions among inpatients (F

conclusionsStandardizing care for agitation in dementia may result in lesser polypharmacy without affecting efficacy. Future studies should assess the ICP in the broader community and outpatients.

Indexed as

Alzheimer DiseasePsychomotor AgitationAgedAged, 80 and overCanadaDouble-Blind MethodFemaleHumansLong-Term CareMalePolypharmacyPsychotropic DrugsTreatment OutcomePsychotropic Drugsagitation in dementiaAlzheimer's diseasebehavioral and psychological symptoms of dementiaintegrated care pathwayneuropsychiatric symptomsnon‐pharmacological interventionspolypharmacy

Identifiers

PMID42504849
PMCPMC13403223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.