ArticleClinical cardiology2026
The Predictive Value of Platelet-to-Lymphocyte Ratio Before and After Percutaneous Coronary Intervention in Patients With Acute ST-Segment Elevation Myocardial Infarction: A Retrospective Cohort Study in Palestine.
Article in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammation and thrombosis influence short-term outcomes after primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI). The platelet-to-lymphocyte ratio (PLR) is an inexpensive marker that may support bedside risk stratification.
objectiveTo assess whether pre-PCI and post-PCI PLR predict in-hospital outcomes and 90-day all-cause mortality in STEMI patients undergoing primary PCI in Palestine.
methodsThis retrospective cohort study included STEMI patients referred for primary PCI at An-Najah National University Hospital. Of 413 eligible patients, 118 were excluded for incomplete records, leaving 295 patients for analysis. PLR was measured before and after PCI and dichotomized using ROC-derived cutoffs: pre-PCI PLR < 21.68 versus ≥ 21.68 and post-PCI PLR < 14.85 versus ≥ 14.85. Outcomes were compared between groups, and multivariable logistic regression was used to assess independent associations.
resultsElevated pre-PCI PLR was associated with greater in-hospital clinical instability and remained independently associated with the composite in-hospital clinical endpoint, both per 10-unit increase (OR 1.41, 95% CI 1.13-1.74; p = 0.002) and using the cutoff ≥ 21.68 (OR 2.90, 95% CI 1.55-5.44; p < 0.001). However, pre-PCI PLR was not independently associated with heart failure or 90-day mortality. Post-PCI PLR showed stronger prognostic value and was independently associated with composite in-hospital events, heart failure, and 90-day mortality, both as a continuous variable and using the cutoff ≥ 14.85.
conclusionPost-PCI PLR demonstrated stronger prognostic value than pre-PCI PLR and may serve as a simple, low-cost adjunctive marker for short-term risk stratification after primary PCI in STEMI patients.
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