ReviewImmunity, inflammation and disease2026
The Diagnostic Challenge of Crohn's Disease With Initial Duodenal Involvement: Two Cases and Literature Review.
Review in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Diagnostic Challenge of Crohn's Disease With Initial Duodenal Involvement: Two Cases and Literature Review.Immunity, inflammation and disease · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundUpper gastrointestinal Crohn's disease (UGI-CD) is rare, with an adult prevalence of 0.5%-4.0%. Its nonspecific symptomatology and the absence of clear diagnostic guidelines pose significant diagnostic challenges. CASE PRESENTATION: We present two patients with UGI-CD treated at Hainan General Hospital. In the first case, a 47-month diagnostic delay led to disease progression and surgical intervention. In the second case, prompt diagnosis of a duodenal ulcer enabled medical management, avoiding surgery. Both patients received infliximab and achieved remission.
conclusionThese cases highlight diagnostic challenges in UGI-CD and offer three key lessons: (i) UGI-CD should be suspected in refractory, Helicobacter pylori-negative duodenal ulcers; (ii) an endoscopic-radiologic mismatch may occur; and (iii) we propose a diagnostic algorithm to assist early recognition, though it has not been prospectively validated. Given the descriptive nature of this two-case series, these findings are hypothesis-generating and require further validation.
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