Observational studyClinical interventions in aging2026
Gut Microbiota in Constipation and Mild Cognitive Impairment: A Mendelian Randomization and Observational Study of Two Common Geriatric Syndromes.
Observational study in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: In geriatric syndrome (GS), conditions like cognitive impairment and constipation reduce quality of life. Gut microbiota may influence GS progression via the gut-brain axis. This exploratory study investigated potential causal associations and microbial characteristics between gut microbiota and constipation, including constipation with mild cognitive impairment. Methods: Two-sample Mendelian randomization (MR) was performed to explore potential causality between gut microbiota and constipation. Inverse variance weighted (IVW) was the primary method, with sensitivity analyses using MR-Egger, weighted median, and MR-PRESSO. False discovery rate (FDR) correction was applied for multiple testing. Two-sample MR used summary statistics from MiBioGen (n=18,340) and FinnGen (51,956 cases). The observational study included 88 participants. Subsequently, fecal samples from 88 elderly participants (30 constipation+MCI, 28 constipation, 30 controls) were analyzed using 16S rDNA sequencing.Gut microbiota was profiled by 16S rDNA V3-V4 sequencing. Alpha diversity (Chao1, Shannon, Simpson) and beta diversity (Bray - Curtis PCoA with Adonis) were assessed. LEfSe (LDA > 4) identified differentially abundant taxa. Functional potential was predicted by Tax4Fun2. Results: MR analysis indicated that the genus Conclusion: The findings offer preliminary evidence that specific gut microbes may be associated with constipation. Distinct microbial features and functional changes are associated with constipation and constipation+MCI. Gut microbiota dysbiosis might link constipation and cognitive impairment, providing exploratory clues rather than definitive conclusions for future hypothesis-driven and microbiota-targeted studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.