ArticleHealth science reports2026
Clinical, Laboratory, and Imaging Characteristics of Liver Involvement in Hospitalized Children With COVID-19 in Iran During 2020-2021: A Cross-Sectional Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Coronavirus disease 2019 (COVID-19) affects multiple organs, including the liver. Although pediatric patients generally experience milder disease, liver involvement has been increasingly reported, and its impact on outcomes remains unclear. This study aimed to evaluate clinical, laboratory, and imaging characteristics of liver involvement in hospitalized children with COVID-19. Methods: We retrospectively analyzed 301 pediatric patients with confirmed COVID-19 admitted to Mofid Children's Hospital, Tehran, Iran, from March 2020 to July 2021 who met the inclusion criteria. Patients were divided into two groups based on liver involvement. Liver involvement was defined as an alanine aminotransferase (ALT) level > 40 IU/L. Variables were compared between groups with and without liver involvement using both univariate and multivariable logistic regression analyses. A Results: Elevated ALT was observed in 84 patients (27.9%). Liver involvement occurred significantly more often in children aged 10 years and older. Patients with hepatic involvement had higher rates of leukopenia, thrombocytopenia, elevated blood urea nitrogen (BUN), tachycardia, hypoxia, pulmonary infiltrations, and shock. The mean hospital stay was longer (7.27 vs. 6.07 days, Conclusion: Liver involvement is common among hospitalized pediatric COVID-19 patients and is associated with worse clinical outcomes, including higher ICU admission and mortality rates. Early recognition and monitoring of hepatic dysfunction may improve management strategies in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.