Evidence map›Paper›PMID 42504185›Full record

ArticleJournal of arthropod-borne diseases2026

Efficacy of a Hemolymph-Based Cream Derived from

Razieh Moghimian, Mehdi Mohebali, Hamid Reza Basseri, Behnaz Akhoundi, Ehsan Salarkia, Abbas Aghaei-Afshar, Kamran Akbarzadeh

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In one paragraph

Article in Journal of arthropod-borne diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Razieh MoghimianDepartment of Biology and Control of Disease Vectors, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi MohebaliCenter for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Hamid Reza BasseriDepartment of Biology and Control of Disease Vectors, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Behnaz AkhoundiDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Ehsan SalarkiaLeishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Abbas Aghaei-AfsharResearch Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
Kamran AkbarzadehDepartment of Biology and Control of Disease Vectors, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cutaneous leishmaniasis (CL) is a neglected tropical disease with limited therapeutic options due to drug resistance, systemic toxicity, and prolonged treatment duration associated with pentavalent antimonials such as meglumine antimoniate (MAT). Methods: Hemolymph was extracted from sterile third-instar Results: Whole hemolymph and the active fraction significantly inhibited parasite growth in vitro, while combination treatments showed strong synergistic effects. Treatments enhanced Th1-associated cytokines, suppressed Th2 cytokines, and increased reactive oxygen species production. In vivo, hemolymph cream reduced lesion size and parasite load, with the greatest improvement observed in the combination group. No significant cytotoxicity was detected. Conclusions:

Indexed as

HemolymphLeishmania majorLucilia sericataMaggot therapyMeglumine antimoniate

Identifiers

PMID42504185
PMCPMC13401833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.