ArticleAnnals of human genetics2026
Structural Variations of Alu Elements in the Kuwaiti Population: Laying the Foundations for Forensic Medicine.
Article in Annals of human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe genetic structure of the Kuwaiti population using Alu insertion variants has not been previously investigated.
objectiveThis study aimed to examine the allele and genotype frequencies of 100 Alu insertion variants in the Kuwaiti population, determine their genetic structure in relation to global populations and evaluate the utility of these markers for inferring geographic ancestry.
methodsDNA was extracted from whole blood samples of 500 unrelated native Kuwaiti citizens across all six governorates. One hundred known Alu elements were amplified via PCR and analysed using gel electrophoresis.
resultsThe mean frequency of the 100 Alu insertions in Kuwaitis was 0.536, showing closer affinity to Eurasian and Indian populations than to sub-Saharan African populations. Analysis of the six Kuwaiti governorates revealed no genetic substructure, suggesting a single genetic cluster. PCA demonstrated that Kuwaitis cluster with geographically adjacent populations, specifically Bahrainis and southern Iranians. Notably, four Alu elements (HS4.32, Ya5NBC120, Yb8NBC106 and Yb8NBC516) were identified as potential markers to distinguish Kuwaitis from other populations.
conclusionThe findings confirm existing global data indicating that the use of Alu elements is a crucial tool for population genetic research, given their unique properties that are generally unavailable for other markers.
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