ReviewJournal of the American Society for Mass Spectrometry2026
Aziridination-Enabled Structural and Quantitative Lipidomics.
Review in Journal of the American Society for Mass Spectrometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Chemical derivatization has long been employed to enhance the structural characterization of lipids by mass spectrometry (MS). In recent years, olefin aziridination has emerged as a powerful and versatile strategy in lipidomics, driven by its ability to selectively target carbon-carbon double bonds (C═C bonds) and to introduce nitrogen-containing functionalities that facilitate both structural elucidation and quantitative analysis. Aziridination-enabled MS approaches provide reliable C═C bond localization through diagnostic fragmentation, while simultaneously improving ionization efficiency, particularly for nonpolar lipid classes. A diverse range of aziridination chemistry has been developed, each offering distinct advantages for lipid analysis. In this review, we summarize recent advances in aziridination-enabled MS methodologies, with an emphasis on reaction development and analytical performance. We further highlight applications across biological and complex sample systems. These developments highlight aziridination-assisted MS as a powerful strategy for precision lipidomics with isomer-resolved capability and accurate quantification.
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