ArticleInorganic chemistry2026
Expansion of the Chemical Space in UiO-Type Metal-Organic Frameworks via the Ugi Four-Component Reaction for Tuned Pore Accessibility.
Article in Inorganic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pore functionalization of metal-organic frameworks (MOFs) remains a superb challenge for controlling intermolecular interactions and the resulting diffusion of guests. Herein, we report a modular presynthetic strategy to expand the chemical space of UiO-67 by incorporating structurally diverse dicarboxylate linkers synthesized via the Ugi four-component reaction (Ugi-4CR). This approach introduces amide-rich functionalities while preserving the fcu topology of the Zr-based framework, as confirmed by PXRD and solid-state 13C NMR spectroscopy. The Ugi-derived functionalization systematically modulates porosity and pore environment, which was further tuned through a multivariate (MTV) mixed-linker strategy. Nitrogen adsorption analysis reveals systematic modulation of surface area and pore accessibility with increasing functionalization. The prepared MOFs were used to adsorb catechol, a prototypical phenolic pollutant, which was quantified by HPLC. The MTV material exhibited the highest uptake, highlighting the interplay between pore accessibility and host-guest interactions, where excessive functionalization hinders adsorption. Overall, this work establishes multicomponent reactions as a versatile platform for tuning pore chemistry in MOFs while emphasizing the need to balance functionality to optimize performance.
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