ArticleGeroScience2026
p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans.
Ali Al Hatem, Boopathi Balasubramaniam, Alissa Villhauer, Ali K Naji, Ransome van der Hoeven
Abstract read
In one paragraphArticle in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Ali Al Hatem *Department of Periodontics and Dental Hygiene, School of Dentistry, University of Texas Health Science Center, Houston, TX, USA.
Boopathi Balasubramaniam *Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA, USA.
Alissa VillhauerIowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA, USA.
Ali K NajiDepartment of Diagnostic and Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Funding
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MPathogen-induced immune and stress responses mediated by bZIP transcription factorsR01AI158429 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VAN DER HOEVEN, RANSOME · 2021 to 2025
$1.9MDivision of Intramural Research, National Institute of Allergy and Infectious Diseases R01 AI158429-6NIAID NIH HHS R01 AI158429NIGMS NIH HHS R24 GM137786NIGMS NIH HHS R24GM137786NIH HHS P40 OD010440
6 · The paper itselfAbstract
Mitis group streptococci are opportunistic pathogens residing in the oral cavity, where they produce hydrogen peroxide (H
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsMetforminp38 Mitogen-Activated Protein KinasesStreptococcal InfectionsTranscription FactorsAnimalsHydrogen PeroxideOxidative StressCaenorhabditis elegans ProteinsDNA-Binding ProteinsHydrogen PeroxideMetforminp38 Mitogen-Activated Protein Kinasesskn-1 protein, C elegansTranscription FactorsCaenorhabditis elegansMDT-15MetforminSKN-1Streptococcus
Identifiers
PMID42503569
PMCPMC13638828
What OpenQuestion holds
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