Evidence map›Paper›PMID 42503454›Full record

ArticleChemistryOpen2026

In Vivo Evaluation of Psoralen in a Copper Sulfate-Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D

Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H Altemani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kishor ChandraDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.
Sharif Uddin BaharDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.ORCID 0009-0006-9423-989X
Khadija AkterDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.
Mst Muslima KhatunDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.ORCID 0009-0004-1801-1928
Samiran SadhukhanDepartment of Pharmaceutical Chemistry, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, West Bengal, India.ORCID 0009-0006-3089-9493
Progna Saha PujaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.
Fazley RohanDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.ORCID 0009-0002-0270-9083
Md Shimul BhuiaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.ORCID 0000-0002-6179-9720
Mohammed AlfaifiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.ORCID 0009-0005-4426-2808
Faisal H AltemaniDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.ORCID 0000-0003-1746-1631
Faisal AlsenaniDepartment of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID 0000-0002-7267-9636
Salehin SheikhDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.ORCID 0009-0002-3705-6967
Muhammad Torequl IslamDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.ORCID 0000-0001-6392-3820

Funding

Deanship of Research and Graduate Studies at King Khalid University RGP1-112-46
6 · The paper itself

Abstract

Psoralen (PSN), a naturally occurring furocoumarin, was evaluated for its antiemetic potential using integrated in vivo and in silico approaches, considering the limitations of currently available antiemetic agents. The antiemetic activity of PSN was investigated in a copper sulfate-induced emesis model using 2-day-old chicks (Gallus gallus domesticus). A dose-dependent experimental design was employed with PSN (5, 10, and 20 mg/kg), alongside standard antiemetics (domperidone 6 mg/kg, ondansetron (OND) 5 mg/kg, and hyoscine 21 mg/kg) and combination treatments. Latency to first retch and total retching episodes were recorded, and percentage inhibition was calculated. Molecular docking was performed against D

Indexed as

AntiemeticsFicusinReceptors, Dopamine D2Receptors, MuscarinicReceptors, Serotonin, 5-HT3VomitingAnimalsChickensCopper SulfateMolecular Docking SimulationAntiemeticsCopper SulfateFicusinReceptors, Dopamine D2Receptors, MuscarinicReceptors, Serotonin, 5-HT3D2 and 5‐HT3 receptorsemesisin vivo chick emesis modelmolecular dockingpsoralen

Identifiers

PMID42503454
PMCPMC13402100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.