Evidence map›Paper›PMID 42503432›Full record

ArticleThe Journal of physiology2026

μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice.

Eva J Kalajian, Marco K Stettler, Gregory D Conradi Smith, Christopher A Del Negro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eva J KalajianDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, Virginia, USA.ORCID https://orcid.org/0009-0005-3760-1541
Marco K StettlerDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, Virginia, USA.
Gregory D Conradi SmithDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, Virginia, USA.ORCID https://orcid.org/0000-0002-1054-6790
Christopher A Del NegroDepartment of Applied Science, School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, Virginia, USA.ORCID https://orcid.org/0000-0002-7848-8224

Funding

Molecular characterization of expiratory breathing-related interneurons in mammalsR21NS134005 · NINDS · COLLEGE OF WILLIAM AND MARY · PI CONRADI SMITH, GREGORY DOUGLAS, DEL NEGRO, CHRISTOPHER A. · 2023 to 2023
$410k
NIH NS134005NIH HHS NS134005NINDS NIH HHS R21 NS134005
6 · The paper itself

Abstract

Opioid-induced respiratory depression (OIRD) is mediated, in part, by μ-opioid receptor (μOR) signalling in the respiratory rhythmogenic preBötzinger complex (preBötC). However, it has been unclear whether opioids affect excitatory or inhibitory neurons, which ion channels are modulated, and by what signalling mechanism. This study clarifies these questions. We quantify Oprm1 (μOR gene) expression in preBötC glutamatergic, GABAergic, and glycinergic neurons and show that 67%-77% of each subpopulation express Oprm1 at commensurate levels, suggesting that all preBötC neurons may respond to opioids. We demonstrate that μOR agonist DAMGO increases passive K

Indexed as

Glutamic AcidG Protein-Coupled Inwardly-Rectifying Potassium ChannelsNeuronsReceptors, Opioid, muRespiratory CenterAnalgesics, OpioidAnimalsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-MaleMiceMice, Inbred C57BLSignal TransductionAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Glutamic AcidG Protein-Coupled Inwardly-Rectifying Potassium ChannelsOprm protein, mouseReceptors, Opioid, mubreathingGIRKinspirationpre‐Bötzinger complexrespiration

Identifiers

PMID42503432
PMCPMC13532837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.