ArticleJournal of cellular and molecular medicine2026
Abelmoschus manihot Polysaccharides Target the AMPK/Nrf2/HO-1 Signalling Pathway to Inhibit Macrophage M1 Polarisation and Hepatic Stellate Cell Activation Improving Liver Fibrosis in Mice.
Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Liver fibrosis (LF) is a critical pathological stage in the progression from chronic liver disease to cirrhosis. While Abelmoschus manihot polysaccharides (AMP) demonstrate hepatoprotective potential, the underlying anti-fibrotic mechanisms remain incompletely understood. A carbon tetrachloride-induced LF mouse model was established followed by AMP intervention. Comprehensive assessments included ELISA measurement of serum biochemical indicators (ALT, AST, ALP, TBA, TBil), fibrosis markers (HA, PC III, LN, Hyp) and inflammatory cytokines (IL-1β, TNF-α, IL-6, IL-10). Liver tissue pathological changes were evaluated through haematoxylin-eosin (HE), Masson and Sirius Red staining. In vitro experiments utilised TGF-β1-stimulated JS-1 and LPS/IFN-γ-induced M1-type RAW264.7 macrophages. Experimental techniques encompassed MTT assay, immunofluorescence, qPCR, Western blot and flow cytometry to analyse cellular markers and signalling pathways. The study specifically investigated AMP's regulatory effects on macrophage polarisation and hepatic stellate cell activation, using the AMPK inhibitor (Compound C) to explore potential mechanistic pathways. AMP treatment effectively mitigated CCl
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