Evidence map›Paper›PMID 42503303›Full record

ArticleAdvanced healthcare materials2026

3D Bioprinted Breast Cancer-Stroma Model with Tailored Migration-Permissive Bioink Reveals Impact of Adipose-Derived Stromal Cells on Cancer Cell Migration and Invasion Dynamics.

Sabrina Stecher, Joachim Schenk, Alessandro Cianciosi, Katherina Hemmen, David Böhringer, Franziska Dusi, Jessica Faber, Philipp Stahlhut, Benedikt Gantert, Emilie Rouenhoff and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sabrina StecherDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0001-5336-7058
Joachim SchenkRudolf Virchow Center, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0003-2100-7319
Alessandro CianciosiChair for Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication, University of Würzburg and Bavarian Polymer Institute, Würzburg, Germany.ORCID https://orcid.org/0009-0009-1314-4437
Katherina HemmenRudolf Virchow Center, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0003-1852-6513
David BöhringerDepartment of Physics, University of Erlangen-Nürnberg, Erlangen, Germany.ORCID https://orcid.org/0000-0002-3880-4069
Franziska DusiDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0009-0006-0131-7490
Jessica FaberInstitute of Continuum Mechanics and Biomechanics, University of Erlangen-Nürnberg, Fürth, Germany.ORCID https://orcid.org/0000-0001-8372-495X
Philipp StahlhutChair for Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication, University of Würzburg and Bavarian Polymer Institute, Würzburg, Germany.ORCID https://orcid.org/0000-0003-1874-1504
Benedikt GantertInstitute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-2930-9912
Emilie RouenhoffDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0009-0003-7719-2768
Annika GmöhlingDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0009-0006-4953-2325
Tessa LühmannInstitute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0001-7552-6435
Jörg TeßmarChair for Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication, University of Würzburg and Bavarian Polymer Institute, Würzburg, Germany.ORCID https://orcid.org/0000-0001-7057-5369
Jürgen GrollChair for Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication, University of Würzburg and Bavarian Polymer Institute, Würzburg, Germany.ORCID https://orcid.org/0000-0003-3167-8466
Silvia BuddayInstitute of Continuum Mechanics and Biomechanics, University of Erlangen-Nürnberg, Fürth, Germany.ORCID https://orcid.org/0000-0002-7072-8174
Tomasz JüngstChair for Functional Materials in Medicine and Dentistry at the Institute of Functional Materials and Biofabrication, University of Würzburg and Bavarian Polymer Institute, Würzburg, Germany.ORCID https://orcid.org/0000-0002-2458-8713
Ben FabryDepartment of Physics, University of Erlangen-Nürnberg, Erlangen, Germany.ORCID https://orcid.org/0000-0003-1737-0465
Katrin G HeinzeRudolf Virchow Center, Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0003-2372-6800
Petra Bauer-KreiselDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0009-0000-0799-2178
Torsten BlunkDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0003-1050-6753

Funding

Deutsche Forschungsgemeinschaft 326 998 133 - TRR 225
6 · The paper itself

Abstract

In breast cancer, local invasion of cancer cells into surrounding tissue marks the first step of metastasis. However, to elucidate the impact of cells from the tumor microenvironment on this process, advanced 3D migration models are still urgently needed. To enable migration and invasion studies in a fully 3D bioprinted tumor-stroma model, a migration-permissive bioink composed of methacrylated collagen type I and thiolated hyaluronic acid with low polymer content is developed. In a printed co-culture model comprising metastatic breast cancer cells (MDA-MB-231) and adipose-derived stromal cells (ASCs), real-time single-cell tracking reveals that ASCs in the stromal compartment profoundly promote migration and invasion dynamics of individual tumor cells. This is reflected by increased speed, migration distance, and invasion into the stroma, and is accompanied by collagen remodeling and a shift in tumor cell morphology. A correlation between tumor cell morphology and migration speed is evident, which is modulated by ASCs. A highly motile and invasive subset of tumor cells is significantly enhanced in the presence of ASCs. These insights into the influence of ASCs on the heterogeneity of breast cancer cells in terms of their migratory behavior may inform the development of more specific and effective treatment options for metastatic breast cancer.

Indexed as

Adipose TissueBioprintingBreast NeoplasmsCell MovementPrinting, Three-DimensionalStromal CellsCell Line, TumorCoculture TechniquesFemaleHumansMDA-MB-231 CellsNeoplasm InvasivenessTumor Microenvironmentbioprintingbreast cancercancerinvasionlive‐cell imagingmigration

Identifiers

PMID42503303
PMCPMC13474114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.