Evidence map›Paper›PMID 42503216›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Supramolecular Polymer-Surfactant Co-Assemblies for Multivalent HSV-1 Inhibition.

Christian Zoister, Boris Schade, Paulina Sittinger, Xianwen Lou, Esmee de Korver, Freek V de Graaf, Ranen Etouki, Chuanxiong Nie, Kai Licha, Kai Ludwig and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christian ZoisterInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Boris SchadeForschungszentrum für Elektronenmikroskopie, Core-Facility BioSupraMol, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Paulina SittingerInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Xianwen LouInstitute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0002-5403-3647
Esmee de KorverInstitute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.
Freek V de GraafInstitute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.
Ranen EtoukiInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Chuanxiong NieInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Kai LichaInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Kai LudwigForschungszentrum für Elektronenmikroskopie, Core-Facility BioSupraMol, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Abhishek Kumar SinghInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-8398-9947
E W MeijerInstitute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands.ORCID https://orcid.org/0000-0003-4126-7492
Rainer HaagInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3840-162X

Funding

Deutsche Forschungsgemeinschaft 431232613 (CRC1449)Deutsche Forschungsgemeinschaft BioSupraMolEuropean Research Council 101055416 (SupraVir)
6 · The paper itself

Abstract

Supramolecular assemblies are of fundamental importance for cellular life and bio-interactive materials. The structure and function of these assemblies are decisively influenced by the design of their molecular components. In this work, we present a modular synthetic strategy for six novel bio-functional surfactants with a sulfonate headgroup (termed SupraVir surfactants). These amphiphilic molecules were designed for strong interactions with viral envelope proteins, virus inhibition, and to co-assemble water-soluble benzene-1,3,5-tricarboxamide derivatives (BTAs) to generate surfactant-grafted supramolecular polymers. Systematic spectroscopic and microscopic studies showed that the morphology of the co-assemblies strongly depends on the surfactant-BTA ratio. At surfactant ratios higher than 1, the native BTA nanofibers were disrupted, resulting in micellar architectures. In the test with herpes simplex virus (HSV-1), fibrous supramolecular polymers show significantly lower half-maximal inhibitory concentrations (IC

Indexed as

Antiviral AgentsHerpesvirus 1, HumanPolymersSurface-Active AgentsBenzamidesMicellesMolecular StructureAntiviral AgentsBenzamidesbenzene-1,3,5-tricarboxamideMicellesPolymersSurface-Active Agentsco‐assemblymultivalentnanofibersupramolecularvirus

Identifiers

PMID42503216
PMCPMC13592328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.