In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
Luiz F Wemmenson Gonçalves MouraPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-5854-6709 Maria Rayane C de OliveiraPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-2568-0519 Gabriela A do NascimentoPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-1183-525X João Gabriel L da SilvaPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0009-0001-8160-6973 Paulo Adenes T CoelhoPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-8566-5201 Lorena S LimaPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0003-3362-2837 Sacha Aubrey A R SantosPrograma de Pós-Graduação em Ciências Fisiológicas (PPGCF), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-4117-2277 Keciany A de OliveiraPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-9928-3826 Francisco Lucas Alves BatistaLaboratório de Bioprospecção de Produtos Naturais e Biotecnologia (LBPNB), Campus CECITEC, Universidade Estadual do Ceará, Tauá, Ceará, Brazil.ORCID https://orcid.org/0000-0002-7543-057X Antonio Eufrásio Vieira-NetoPrograma de Pós-Graduação em Ciências Fisiológicas (PPGCF), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-7003-6461 Stenio F FélixGrupo de Pesquisa Química de Produtos Naturais e Atividades Biológicas do Semiárido (QPNBioS), Instituto Federal do Ceará, Campus Iguatu, Iguatu, Ceará, Brazil.ORCID https://orcid.org/0000-0002-0747-6541 Solange de O PinheiroPrograma de Pós-Graduação em Ciências Naturais (PPGCS) e, Rede Nordeste de Biotecnologia (RENORBIO), Laboratório de Análises Cromatográficas e Espectroscópicas (LACES), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-9063-2877 Maria Izabel Florindo GuedesPrograma de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia (RENORBIO), Programa de Pós-Graduação em Ciências Médicas (PPGCM), Núcleo de Biologia Experimental (NUBEX), Universidade de Fortaleza, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-4569-8663 Renalison Farias-PereiraPrograma de Pós-Graduação em Química Biológica (PPGQB), Laboratório de Microbiologia e Biologia Molecular (LMBM), Universidade Regional do Carriri - URCA, Crato, Ceará, Brazil.ORCID https://orcid.org/0000-0002-8608-2347 Adriana R CamposPrograma de Pós-Graduação em Ciências Fisiológicas (PPGCF), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-7355-9310 Francisco Ernani A MagalhãesPrograma de Pós-Graduação em Nutrição e Saúde (PPGNS), Laboratório de Química Inorgânica (LQUIN), Campus do Itaperi, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0002-4924-2882 Funding
FUNCAP FPD-0213-00140.01.00/23FUNCAP PS1-00186-00240.01.00/21FUNCAP UNI-0210-00160.01.00/23UNIFOR
6 · The paper itselfAbstract
Lippia grata Schauer, a species of the Verbenaceae family, is native to the Northeastern region of Brazil and widely distributed in the Seasonally Dry Tropical Forest. Commonly known as "alecrim-da-chapada," this medicinal plant stands out for its antimicrobial and pharmacological properties, mainly due to its essential oils rich in thymol and carvacrol. These compounds confer antifungal, antibiotic, anti-inflammatory, antioxidant, and antitumor activities, highlighting their potential in folk medicine. Based on this, the present study aimed to use in silico and in vivo tests in adult zebrafish as an alternative method to investigate the therapeutic potential of the essential oil of Lippia grata (EOLg) and its main constituent thymol (2-isopropyl-5-methylphenol) in the treatment of seizures and anxiety induced by alcohol withdrawal. Initially, adult zebrafish (n = 6/group) were treated with EOLg and thymol (0.01 or 0.1 or 1.0 mg/mL; 20 µL; oral administration) and assessed for anxiolytic, convulsive, and acute toxicity effects after 96 h. Subsequently, the potential anxiolytic-like, anticonvulsant effects, the possible GABAergic mechanism, and the efficacy of the samples in treating anxiety induced by alcohol withdrawal in adult zebrafish were investigated. Furthermore, molecular docking simulations of thymol with GABAergic receptors were performed. Preliminary results showed that EOLg and thymol were nontoxic and did not exhibit sedative effects in ZFa. Both demonstrated anticonvulsant and anxiolytic effects involving GABA
Indexed as
Anti-Anxiety AgentsAnticonvulsantsAnxietyLippiaOils, VolatileSeizuresThymolAnimalsDose-Response Relationship, DrugMolecular Docking SimulationReceptors, GABA-AZebrafishAnti-Anxiety AgentsAnticonvulsantsOils, VolatileReceptors, GABA-AThymoladult zebrafish (Danio rerio)anxietyGABAALippia grataseizurethymol
Identifiers
PMID42503215
PMCPMC13401972
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