Evidence map›Paper›PMID 42503202›Full record

ArticleChemistry & biodiversity2026

Nudiloid Z, a New Labdane-Type Diterpenoid From Callicarpa nudiflora With Anti-Inflammatory Activity.

Qi Li, Bo Li, Yan-Ling Tang, Xue-Ting Ji, Muhammad Aurang Zeb, Yan-Zi Ma, Yuan-Lin Kong, Zhong-Dan Liang, Xiao-Li Li, Xing-Jie Zhang and 1 more

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qi LiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Bo LiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Yan-Ling TangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Xue-Ting JiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Muhammad Aurang ZebKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Yan-Zi MaKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Yuan-Lin KongKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Zhong-Dan LiangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Xiao-Li LiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Xing-Jie ZhangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Wei-Lie XiaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Chemical Science and Technology, Yunnan University, Kunming, China.

Funding

Applied Basic Research Foundation of Yunnan Province 202401AT070444Applied Basic Research Foundation of Yunnan Province 202501BC070005Applied Basic Research Foundation of Yunnan Province 202603AD140002National Natural Science Foundation of China 22467022National Natural Science Foundation of China 22477108National Natural Science Foundation of China U24A20805The Practical Innovation Project of Postgraduate Students in the Professional Degree of Yunnan University ZC-252513838Yunnan Characteristic Plant Screening and R&D Service CXO Platform 2022YKZY001
6 · The paper itself

Abstract

A new labdane-type diterpenoid, Nudiloid Z (1), together with twelve known compounds (2-13), were isolated and purified from the stems and leaves of Callicarpa nudiflora. Compound 1 possesses a three-membered epoxide ring at C-12 and C-13. The planar structure and absolute configuration of 1 were elucidated by comprehensive spectroscopic analyses. The inhibitory effects of compounds 1-3 and 8 on lactate dehydrogenase (LDH) release in J774A.1 cell was evaluated. The results indicated that compound 1 exhibited significant anti-inflammatory activity, with an inhibitory concentration 50% (IC

Indexed as

Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCallicarpaDiterpenesAnimalsCell LineDose-Response Relationship, DrugInterleukin-1betaLipopolysaccharidesL-Lactate DehydrogenaseMacrophagesMiceMolecular ConformationMolecular StructurePlant LeavesPlant StemsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalDiterpenesInterleukin-1betaLipopolysaccharidesL-Lactate Dehydrogenaseanti‐inflammatoryCallicarpa nudifloralabdane diterpenoidssesquiterpenoids

Identifiers

PMID42503202
PMCPMC13401971

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.