Evidence map›Paper›PMID 42503156›Full record

ArticleClinical journal of gastroenterology2026

Multimodal approach enables R0 resection in advanced gastric adenocarcinoma with enteroblastic differentiation complicated by portal vein tumor thrombus.

Masateru Yamauchi, Keiji Nishibeppu, Takeshi Kubota, Hiroyuki Inoue, Kazuya Takabatake, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Hitoshi Fujiwara, Atsushi Shiozaki

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In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Masateru YamauchiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Keiji NishibeppuDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. nishibe@koto.kpu-m.ac.jp.ORCID http://orcid.org/0000-0003-2921-9498
Takeshi KubotaDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Hiroyuki InoueDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Kazuya TakabatakeDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Toshiyuki KosugaDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Hirotaka KonishiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Ryo MorimuraDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Hitoshi FujiwaraDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Atsushi ShiozakiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric adenocarcinoma with enteroblastic differentiation (GAED) is an extremely rare gastric cancer subtype with high rates of vascular and lymphatic invasion, lymph node and liver metastasis, leading to poor prognosis and early recurrence. We report a 73-year-old woman with stage IV GAED and portal vein tumor thrombus (PVTT) treated with multimodal therapy. She received S-1 plus oxaliplatin (SOX), SOX plus nivolumab, S-1 plus nivolumab, and radiotherapy for PVTT without major adverse events. Imaging showed marked tumor and lymph node shrinkage and complete PVTT disappearance. Laparoscopic distal gastrectomy with D2 dissection achieved R0 resection; pathology confirmed GAED, ypT2N1M0, Stage IIA, with Grade 1b response. This case suggests SOX plus nivolumab is effective for advanced GAED and that radiotherapy for PVTT enables curative surgery. Preoperative chemoradiotherapy and conversion surgery may provide a promising strategy for otherwise unresectable GAED.

Indexed as

AdenocarcinomaPortal VeinStomach NeoplasmsVenous ThrombosisAgedAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleGastrectomyHumansTegafurTegafurConversion surgeryGastric cancerPortal vein tumor thrombus

Identifiers

PMID42503156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.