ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2026
Development and psychometric evaluation of a new itch assessment questionnaire for use in multi-ethnic Asian population.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe study aimed to develop and evaluate an itch assessment questionnaire (IAQ) to determine and monitor itch severity and its impact on quality of life (QOL) in a multi-ethnic Asian population. It addresses limitations of existing tools, which assess only narrow aspects of itch and require multiple instruments for a comprehensive evaluation of itch and its impact on patients' QOL. No single, validated multidimensional questionnaire currently reflects the cultural and ethnic diversity of Asian populations.
methodsAn exploratory, sequential, mixed-methods study was conducted in two phases in a primary care setting in Singapore. Phase one used literature review, preliminary qualitative study findings, expert discussions and qualitative interviews with 13 patients and 10 primary care physicians to develop a draft IAQ. In phase two, 250 participants (with and without itch) completed the draft IAQ, 5-D pruritus scale, and Dermatology Life Quality Index (DLQI) over three points, 4-10 days apart. Data was analysed to assess IAQ's validity and reliability.
resultsThe final IAQ comprised 10 questions across three parts: itch severity, impact on QOL, and itch management. The IAQ demonstrated a strong correlation with the 5-D pruritus scale (ρ = 0.67, p < 0.001) and DLQI (ρ = 0.77, p < 0.001). The overall intraclass correlation coefficient and Cronbach α were 0.93 (95% CI = 0.91 to 0.95) and 0.94 (95% CI = 0.93 - 0.95), respectively.
conclusionsIAQ demonstrated construct validity and excellent reliability, suggesting its suitability for assessing itch severity and impact on QOL in multi-ethnic Asian populations.
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