Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
M Margarida MartinsDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0000-0003-3846-8250
Ruben ValenteDepartamento de Ciências da Vida, Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA, University Lisbon, Caparica, Portugal.ORCID https://orcid.org/0000-0001-6534-4128
Ruben AmaroDepartamento de Ciências da Vida, Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA, University Lisbon, Caparica, Portugal.ORCID https://orcid.org/0009-0002-2434-6308
Maria S VianaDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0000-0002-1901-7000
Rita de JesusDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0009-0003-2327-8136
Bernardo BragaDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.
Daniela PeixotoDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0000-0001-8319-6894
Celina SchenkelbergerDepartamento de Ciências da Vida, Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA, University Lisbon, Caparica, Portugal.
Matilde SimãoDepartamento de Ciências da Vida, Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA, University Lisbon, Caparica, Portugal.
Pedro V BaptistaDepartamento de Ciências da Vida, Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA, University Lisbon, Caparica, Portugal.ORCID https://orcid.org/0000-0001-5255-7095
Paula S BrancoDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0000-0002-7312-8596
João Aires-de-SousaDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0000-0002-5887-2966
Alexandra R FernandesDepartamento de Ciências da Vida, Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA, University Lisbon, Caparica, Portugal.ORCID https://orcid.org/0000-0003-2054-4438
Luísa M FerreiraDepartment of Chemistry, LAQV REQUIMTE, Associated Laboratory from Green Chemistry, NOVA School of Science and Technology, NOVA FCT, Caparica, Portugal.ORCID https://orcid.org/0000-0001-8474-3925
Funding
Fundação para a Ciência e a Tecnologia 2022.09845.BDFundação para a Ciência e a Tecnologia LA/P/0008/2020Fundação para a Ciência e a Tecnologia LA/P/0140/2020Fundação para a Ciência e a Tecnologia UI/BD/151278/2021Fundação para a Ciência e a Tecnologia UID/04378/2025Fundação para a Ciência e a Tecnologia UID/50006/2025Fundação para a Ciência e a Tecnologia UID/PRR/04378/2025Fundação para a Ciência e a Tecnologia UID/PRR/50006/2025
6 · The paper itself
Abstract
The development of new therapeutic agents for glioblastoma and hepatocellular carcinoma (HCC) remains a priority due to poor prognosis, limited treatment options, and high recurrence rates. Herein, we report a one-pot synthesis of aromatic aminopropyl lactams (ArAPLs) via hydrolysis of bicyclic amidines (DBN, DBU), followed by reductive amination with aromatic aldehydes. These compounds were designed to target histamine H
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Synthesis and Biological Activity of Novel Aromatic Aminopropyl Lactams in Two Cancer Cell Models. · full record | OpenQuestion