ReviewChemMedChem2026
Nucleobase Amino Acids in the Development of Amide-Linked Oligonucleotide Mimics.
Review in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although peptide nucleic acids (PNAs) have been extensively used in antisense strategies, the lack of any side chain in the PNA backbone deprives them of having any protein-like tertiary structures, limiting their use in nucleic acid-protein interactions. To overcome this limitation, scientists have developed hybrid monomeric structures like nucleobase amino acids (NBAs) where canonical nucleobases are covalently attached to natural or unnatural amino acid side chains, making them amenable to incorporation into peptides, proteins, and PNAs using solid- or solution-phase peptide synthesis. The resulting assemblies are capable of recognizing their complementary oligonucleotides as well as having the ability to form well-defined secondary/tertiary protein-like structures for enhanced nucleic acid-protein interactions. This perspective article chronicles the developments in this area of research over the years.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.