ArticleChemistry, an Asian journal2026
Visible-Light-Driven Photoredox-Catalyzed Reduction of Nitro (Hetero)arenes to (Hetero)aryl Amines and Subsequent C─N Bond-Forming Reactions.
Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A sustainable and efficient visible-light photoredox catalytic strategy was developed for the selective reduction of nitro(hetero)arenes to the corresponding amino(hetero)arenes, followed by in situ C─N coupling, using a Cu-Ti-gCN composite as non-noble photocatalyst. The reduced products were obtained in good to excellent yields (up to 95%) under mild reaction conditions and exhibits a broad substrate scope, accommodating halogenated, heteroaromatic, and fused nitroarenes. Mechanistic studies, supported by radical-quenching experiments, indicate a multisite proton-coupled electron transfer (MS-PCET) pathway involving key radical intermediates. The application of the method was further extended to reductive cyclization reactions, providing access to biologically relevant N-heterocycles.
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