ArticleACR open rheumatology2026
Factors Associated With Intermittent and Constant Pain Patterns in People With Gout: A Cross-Sectional Analysis.
Article in ACR open rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveAlthough gout is traditionally conceptualized as an episodic disease characterized by acute flares and symptom-free intercritical periods, some individuals report persistent joint pain that extends beyond flares. This cross-sectional analysis aimed to explore factors associated with self-reported pain patterns (constant vs intermittent) in people with gout.
methodsThis cross-sectional analysis was performed on data from 90 participants with physician-diagnosed gout who completed clinical assessments and patient-reported outcome measures. Pain patterns were classified using participant-selected validated graphical representations representing intermittent and constant pain patterns. Multivariable logistic regression was used to identify factors independently associated with constant pain. Model discrimination was assessed using the area under the receiver operating characteristic curve (ROC AUC).
resultsOne-third of participants (34.4%) reported a constant pain pattern. The final regression model indicated that constant pain was independently associated with younger age of gout onset (adjusted odds ratio [aOR] 0.86, 95% confidence interval [CI] 0.79-0.93), greater activity limitation (aOR 5.75, 95% CI 1.43-23.01), and current co-existing anxiety or depression (aOR 9.21, 95% CI 1.39-60.91). The regression model demonstrated good discrimination between participants with constant and intermittent pain patterns with an ROC AUC of 0.82 (95% CI 0.73-0.91).
conclusionA substantial proportion of people with gout experience constant pain, which is linked to early disease onset, functional impairment, and mood disturbance. These hypothesis-generating findings suggest that the model of pain-free intercritical gout may not apply to all people with gout and may emphasize the need for tailored management strategies for people with gout.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.