Evidence map›Paper›PMID 42502854›Full record

ArticlePeerJ2026

Influence of vessel-depleted neck and risk factors on vascularized free flap failure: a retrospective cohort study and predictive model.

Pingchuan Ma, Guile Zhao, Guanru Wang, Yufei Hua, Zhiyong Guo, Longjiang Li, Chunjie Li

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In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Pingchuan Ma *State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Guile Zhao *State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Guanru WangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Yufei HuaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Zhiyong GuoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Longjiang LiState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Chunjie LiState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The vessel-depleted neck represents a distinct clinical entity in free flap reconstruction, yet its impact on flap outcomes remains controversial. This study aimed to compare the rate of free flap failure between vessel-depleted neck cases and ordinary cases in head and neck reconstruction, and to identify risk factors for flap failure while developing a perioperative predictive model. Methods: We analyzed all vascularized free flap cases performed at our institution between July 2021 and June 2024. Cases were divided into training and testing sets based on surgery time. The association between vessel-depleted neck and flap failure was assessed. Multivariate logistic regression analysis was performed to identify independent risk factors for flap failure in the training set. A predictive model was subsequently constructed and validated using the testing set. Results: Among 1,965 free flap cases in analysis, 61 cases in the training set ( Conclusion: There was no significant difference in flap failure rates between vessel-depleted neck cases and ordinary cases. Liver disease, titanium plate use, maxillary disease location, and surgical site infection were identified as significant risk factors for flap failure. The developed predictive model demonstrated clinically useful discriminatory ability.

Indexed as

Free Tissue FlapsNeckPlastic Surgery ProceduresAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsFree flap failureHead and neck reconstructionNomogramVascularized free flap transplantationVessel-depleted neck

Identifiers

PMID42502854
PMCPMC13401362

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