Evidence map›Paper›PMID 42502822›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Tetrathiomolybdate reduces bone cancer pain and tumor-associated osteoclast activation through copper-dependent LOX signaling.

Haonan Yu, Xinru Yuan, Xin Li, Jiayu Tong, Chengya Huang, Xingji You, Jingxiang Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haonan YuSchool of Medicine, Shanghai University, Shanghai 200444, China.
Xinru YuanSchool of Medicine, Shanghai University, Shanghai 200444, China.
Xin LiDepartment of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200030, China.
Jiayu TongSchool of Medicine, Shanghai University, Shanghai 200444, China.
Chengya HuangDepartment of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200030, China.
Xingji YouSchool of Medicine, Shanghai University, Shanghai 200444, China.
Jingxiang WuDepartment of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone cancer pain (BCP) affects most patients with bone metastases and is poorly managed by current analgesics. This study evaluated tetrathiomolybdate (TTM), a clinical copper chelator, for its potential to simultaneously target osteoclast activation and copper-dependent tumor growth in BCP. Using a mouse model with intrafemoral Lewis lung carcinoma cells, TTM (20-40 mg·kg

Indexed as

Bone cancer painCopper chelationLysyl oxidaseNociceptionOsteoclastsTetrathiomolybdate

Identifiers

PMID42502822
PMCPMC13400248

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.