ArticleFood science & nutrition2026
Quercetin (Que) Improved the Biological Activity of Preeclampsia Cells by Inhibiting Autophagy.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Quercetin, a phytochemical sourced from botanicals, exhibits therapeutic potential for conditions including preeclampsia (PE); nevertheless, its precise mechanisms of action against this condition remain incompletely characterized. This investigation sought to explore the hypothesis that quercetin enhances cellular function in PE by suppressing autophagy during in vitro experiments. Within an oxygen-deprived setting, placental trophoblast cells were generated and subsequently exposed to varying doses of Quercetin (Que) alongside LY294002, a compound inhibiting PI3K activity. Cellular multiplication, programmed cell death, and invasive capacity were quantified. This evaluation employed tetrazolium salt (MTT) testing, fluorescence-activated cell sorting, Transwell chamber analysis, and scratch wound closure measurements. Furthermore, subcellular architecture was visualized through electron microscopic imaging, while immunoblot analysis determined expression levels of associated proteins. Relative to controls, HTR-8/SVneo cells exhibited markedly suppressed proliferation, invasive capacity, and 24-h/48-h scratch assay closure rates, alongside substantially elevated apoptotic activity (
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