ArticleIranian journal of pharmaceutical research : IJPR
Investigating the Anti-inflammatory Mechanism of
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Objectives: This study aimed to elucidate the molecular mechanisms underlying the anti-inflammatory activity of Methods: The EEAP was analyzed for proximate composition, vitamin C content, total phenolic content (TPC), total flavonoid content (TFC), total monomeric anthocyanin content (TMAC), and metabolite profile, followed by a network pharmacology analysis. Cytotoxicity was evaluated in HEK-293 cells. An in vivo study of carrageenan-induced paw edema in rats was conducted to validate the findings. Results: EEAP contained 42.12% ash, 34.66% moisture, 6.03% protein, 16.60% fat, and 0.59% carbohydrate. The vitamin C content was 941.55 mg/100 g extract, the TPC was 452.9 mg GAE/100 g extract, the TFC was 416.1 mg QUE/100 g extract, and the TMAC was 2770 mg/100 g extract. Functional enrichment analysis identified the TLR4/MyD88 signaling pathway as contributing to IL-23 production. Eight metabolites with anti-inflammatory properties were verified based on their Pa values: glycidyl oleate, 1-stearoylglycerol, alpha-linolenic acid, methyl palmitate, shogaol, 4-methoxybenzaldehyde, ginkgoneolic acid, and curcumene. EEAP was not toxic to HEK-293 cells (IC Conclusions: EEAP is not toxic to normal cells and exerts an anti-inflammatory effect by reducing edema volume in carrageenan-induced rats; however, it does not alter the TLR4/MyD88 pathway.
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